Immunobullous Disorder: A Diagnostic Dilemma Faced at a Tertiary Care Centre in Kanyakumari, Tamil Nadu, India
نویسندگان
چکیده
Introduction: Immunobullous disorders are morphologically heterogenous and hence the differentiation between various subtypes is essential for proper treatment prognosis. Prompt diagnosis needs clinicopathological concordance added with Immunofluorescence (IF) in particular Direct (DIF) study to avoid discrepancies. Aim: To profile along immunological features analyse utility of IF DIF immunobullous disorders. Materials Methods: The present was a single institution based cross-sectional observational hospital done department pathology SreeMookambika Institute Medical Sciences, Tamil Nadu over period one year (July 2019-August 2020) involving 70 outpatients dermatology clinical evidence bullous Two biopsies were taken from patient, newly formed bulla or vesicle Haematoxylin Eosin (H&E) stain other perilesional normal looking skin study. Statistical analysis by using SPSS software. Chi-square test used statistical analysis. A p-value less than 0.05 considered as statistically significant. However, final arrived after considering clinical, bedside investigations, histopathology Results: Out seventy (70) patients included this study, most common age group distribution 51-60 years frequency 22 (31.4%). patients, 39 diagnosed intraepidermal 31 subepidermal disorder on findings Pemphigus Vulgaris (PV) (44.3%) followed Bullous Pemphigoid (BP) 23 (32.9%). PV 33 (47.1%). Clinical histopathological conclusive cases PV. percentage positive 67 (95.71%). Patients which reached inconclusive (DIF not definite) only three patients. Conclusion: Since, there occurs an overlap features, particular, plays sensitive tool confirming well distinguishing
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ژورنال
عنوان ژورنال: National journal of laboratory medicine
سال: 2023
ISSN: ['2277-8551', '2455-6882']
DOI: https://doi.org/10.7860/njlm/2023/58223.2739